Jeffrey M Zigman Selected Research

Ghrelin

1/2022	A closer look at alcohol-induced changes in the ghrelin system: novel insights from preclinical and clinical data.
11/2021	LEAP2 deletion in mice enhances ghrelin's actions as an orexigen and growth hormone secretagogue.
1/2021	"A LEAP 2 conclusions? Targeting the ghrelin system to treat obesity and diabetes".
1/2021	Genetic deletion of the ghrelin receptor (GHSR) impairs growth and blunts endocrine response to fasting in Ghsr-IRES-Cre mice.
1/2021	Ghrelin cell-expressed insulin receptors mediate meal- and obesity-induced declines in plasma ghrelin.
11/2020	Combined Loss of Ghrelin Receptor and Cannabinoid CB1 Receptor in Mice Decreases Survival but does not Additively Reduce Body Weight or Eating.
1/2020	Acyl-ghrelin Is Permissive for the Normal Counterregulatory Response to Insulin-Induced Hypoglycemia.
1/2020	Ghrelin Protects Against Insulin-Induced Hypoglycemia in a Mouse Model of Type 1 Diabetes Mellitus.
1/2020	Lowering oxidative stress in ghrelin cells stimulates ghrelin secretion.
1/2019	LEAP2 changes with body mass and food intake in humans and mice.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Jeffrey M Zigman Research Topics

Disease

27	Body Weight (Weight, Body) 11/2021 - 09/2003
15	Obesity 11/2021 - 12/2005
9	Hypoglycemia (Reactive Hypoglycemia) 11/2021 - 05/2007
6	Starvation 11/2021 - 03/2014
6	Hyperphagia (Overeating) 12/2018 - 11/2008
5	AIDS-Related Complex (ARC) 01/2021 - 06/2003
5	Insulin Resistance 01/2020 - 12/2008
3	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2020 - 01/2017
3	Weight Gain 01/2015 - 04/2007
2	Hyperglycemia 01/2019 - 01/2017
2	Weight Loss (Weight Reduction) 01/2016 - 10/2014
2	Glucose Intolerance 01/2016 - 06/2011
2	Post-Traumatic Stress Disorders (Post Traumatic Stress Disorder) 07/2011 - 06/2010
1	Alcoholism (Alcohol Abuse) 01/2022
1	Type 2 Diabetes Mellitus (MODY) 01/2020
1	Alzheimer Disease (Alzheimer's Disease) 01/2019
1	Prader-Willi Syndrome (Syndrome, Prader-Willi) 12/2018
1	Papillary Thyroid Cancer 05/2013
1	Carcinoma (Carcinomatosis) 05/2013
1	Follicular Adenocarcinoma 05/2013
1	Hepatic Encephalopathy 01/2012
1	Metabolic Syndrome (Dysmetabolic Syndrome X) 06/2010
1	Abdominal Obesity 06/2009
1	Hypothyroidism 12/2003

Drug/Important Bio-Agent (IBA)

33	GhrelinIBA 01/2022 - 09/2003
12	Ghrelin ReceptorsIBA 01/2022 - 12/2005
11	Blood Glucose (Blood Sugar)IBA 11/2021 - 01/2016
9	Insulin (Novolin)FDA Link 01/2021 - 05/2007
7	Hormones (Hormone)IBA 01/2021 - 09/2003
5	acyl-ghrelinIBA 11/2021 - 01/2019
5	Glucose (Dextrose)FDA LinkGeneric 01/2021 - 05/2007
5	LeptinIBA 02/2012 - 09/2003
4	Serotonin (5 Hydroxytryptamine)IBA 12/2010 - 06/2003
4	Pro-Opiomelanocortin (Proopiomelanocortin)IBA 12/2010 - 06/2003
3	Insulin ReceptorIBA 01/2021 - 04/2010
3	Messenger RNA (mRNA)IBA 03/2014 - 01/2006
3	Estradiol (Delestrogen)FDA LinkGeneric 03/2014 - 04/2007
2	Proteins (Proteins, Gene)FDA Link 01/2021 - 05/2016
2	Hypoglycemic Agents (Hypoglycemics)IBA 01/2021 - 01/2020
2	SecretagoguesIBA 11/2020 - 12/2018
2	Streptozocin (Streptozotocin)FDA Link 01/2020 - 01/2017
2	Peptide Hormones (Polypeptide Hormones)IBA 01/2020 - 01/2013
2	Glucagon (Glukagon)FDA Link 01/2017 - 05/2007
2	Neuropeptide YIBA 05/2016 - 04/2007
2	Peptides (Polypeptides)IBA 01/2015 - 12/2012
2	LipidsIBA 06/2010 - 06/2009
1	AcyltransferasesIBA 01/2022
1	LigandsIBA 11/2021
1	des-n-octanoyl ghrelinIBA 01/2021
1	CB1 Cannabinoid Receptor (CB1 Receptor)IBA 11/2020
1	CannabinoidsIBA 11/2020
1	Somatotropin Receptors (Growth Hormone Receptor)IBA 11/2020
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 01/2020
1	Epinephrine (Adrenaline)FDA LinkGeneric 01/2020
1	Dopamine Receptors (Dopamine Receptor)IBA 01/2019
1	Insulin-Like Growth Factor I (IGF-1)IBA 12/2018
1	Glucagon Receptors (Glucagon Receptor)IBA 01/2017
1	Amino Acids FDA Link 01/2015
1	RacivirIBA 05/2013
1	Antidepressive Agents (Antidepressants)IBA 05/2013
1	NeurotensinIBA 12/2012
1	Glucagon-Like Peptide 1 (GLP 1)IBA 12/2012
1	Secretin FDA Link 12/2012
1	AcidsIBA 01/2012
1	6-chloro-2-(1-piperazinyl)pyrazine (CPP)IBA 07/2011
1	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 06/2011
1	HDL CholesterolIBA 06/2010
1	Triglycerides (Triacylglycerol)IBA 06/2010
1	OrexinsIBA 05/2010
1	Nonesterified Fatty Acids (NEFA)IBA 12/2008
1	EnzymesIBA 05/2007
1	Deoxyglucose (2 Deoxy D glucose)IBA 05/2007
1	AntimetabolitesIBA 05/2007
1	Glutamic Acid (Glutamate)FDA Link 05/2007
1	NeuropeptidesIBA 04/2007
1	Agouti-Related ProteinIBA 04/2007
1	Melanocortin Receptors (Melanocortin Receptor)IBA 07/2006
1	Thyroxine (Levothyroxine)FDA LinkGeneric 12/2003
1	Thyroid HormonesIBA 12/2003
1	Appetite Depressants (Anorectics)IBA 06/2003

Therapy/Procedure

2	Caloric Restriction 11/2021 - 01/2016
2	Gastric Bypass (Roux-en-Y Gastric Bypass) 01/2019 - 10/2014
1	Gastrectomy 01/2019
1	Glycemic Control 11/2014